cd20 vs cd19
-. Pedro Horna, Grzegorz Nowakowski, Jan Endell, Rainer Boxhammer; Comparative Assessment of Surface CD19 and CD20 Expression on B-Cell Lymphomas from Clinical Biopsies: Implications for Targeted Therapies. Results: Conclusions: Both of the two antigens were negative in 29 patients with acute T lymphoblastic leukemia and 7 patients with T/My AMLL. |
NIH 2012;2012:645-51. doi: 10.1182/asheducation-2012.1.645. 1995 Dec;9(4):234-50. doi: 10.1016/s0268-960x(95)90015-2. USA.gov. Aims:
Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Of eight additional cases studied post-anti-CD20 immunotherapy (6-84 months after last dose), the percentage of antigen-positive events by tumor cells was largely preserved for both CD19 (median=99.6%, range=93.5-100%) and CD20 (median=95.7%, range=55.6-100%), similar to the pre-therapy cohort. Get the latest research from NIH: https://www.nih.gov/coronavirus. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Population Pharmacokinetics of Blinatumomab in Pediatric and Adult Patients with Hematological Malignancies. Quantitative determination of CD19 and CD20 may provide useful diagnostic information for the study of B lymphoproliferative disorders. HHS However, CD20 expression was more heterogeneous (within individual patient samples and across patients), with a higher median percentage of CD20-negative tumor events (median=0.5%, range=0-98%) compared with CD19-negative events (median=0%, range=0-28%) (p=0.003).
1999 Sep;102(3):753-62. doi: 10.1038/s41375-020-0792-2. In addition, percentages of CD19/CD20 double-negative tumor events were very small (median=0%, range=0-4.9%), and only detectable in 15 cases (32%). HHS These indicate that CD19 may be a better antibody targeting molecule than CD20 for patients with B-lineage acute leukemia.
Chen YH, Tang YM, Shen HQ, Song H, Yang SL, Shi SW, Qian BQ, Xu WQ, Ning BT. CD20-targeting agents have been broadly integrated into the therapeutic armamentarium for B-cell lymphomas.
The difference of the fluorescence intensity between the two antigens on the cells from each patient with B lineage ALL or B/My AMLL was statistically significant (t = 20.68, P < 0.001). 2004 Mar;42(3):188-91. Clipboard, Search History, and several other advanced features are temporarily unavailable. Get the latest public health information from CDC: https://www.coronavirus.gov. In order to provide the evidences for CD19 as a better antibody targeting molecule for B lineage acute leukemias than CD20 through the multi-parameter flow-cytometry analysis of leukemia cells, the samples from 321 patients with acute leukemia (AL) were immunophenotyped by multi-color flow cytometry and CD45/SSC gating strategy followed by the analysis of CD19 and CD20 expression. The pathology of the chronic lymphoid leukaemias. CD19 is a less specific marker of B cell lineage; it is expressed on earlier progenitors starting at the pre-B cell stage.
Epub 2011 Jan 26. Biopsies from eight additional patients with persistent/recurrent B-cell lymphomas after anti-CD20 therapy (greater than 6 months after last dose) were also evaluated. Horna:MorphoSys AG: Research Funding. Quantitative analysis of CD79b, CD5 and CD19 in mature B-cell lymphoproliferative disorders. USA.gov. The results identified distinct profiles of CD19 and CD20 expression in the various types of B cell leukaemias.
2002 Aug;16(8):1460-9. doi: 10.1038/sj.leu.2402584.
-, Leukemia.
| When compared with background benign B-cells, CD20 was frequently overexpressed on tumor cells (mean MFR=1.8), while CD19 expression was overall similar to background benign B-cells (mean MFR=0.9) (p=0.001). 2011 Sep;79(3):330-43. doi: 10.1016/j.critrevonc.2010.12.003. NCI CPTC Antibody Characterization Program, J Immunol. B- and T-cell prolymphocytic leukemia: antibody approaches. Curr Oncol Rep. 2020 Apr 16;22(5):42. doi: 10.1007/s11912-020-00911-0. 2017 Jun 30;7(6):e577.
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